If a mutation causes a reduction in the production of demethylase, the expected effect will be _______ in the amount of overall methylation and therefore _______ in overall gene expression.
A) an increase; an increase
B) an increase; a decrease
C) no change; an increase
D) a decrease; an increase
E) a decrease; a decrease

Question

Quizplus · Accepted Answer

Demethylase enzymes remove methyl groups from DNA, typically leading to increased gene expression by making the DNA more accessible for transcription. A reduction in demethylase production would result in increased methylation (as fewer methyl groups are removed), which generally suppresses gene expression.

If a Mutation Causes a Reduction in the Production of Demethylase