A hypothetical drug has a side effect of increasing blood pressure.Individuals who are homozygous T at SNP 1 break down this drug faster than average.Individuals who are homozygous A at SNP 2 break down this drug slower than average.The effects of these two SNPs roughly cancel each other out, such that homozygotes at both SNPs generally have average rates of breakdown of the enzyme.Which individual is most likely to be at risk for having the side effect? (Note: The genotype of SNP 1 is presented first, followed by that of SNP 2.)

Question

Quizplus · Accepted Answer

Individual C (TC, AA) is most likely to be at risk for having the side effect because they have one allele that slows down the drug breakdown (AA at SNP 2) without having both alleles that speed up the breakdown (TC at SNP 1 indicates only one allele for faster breakdown). This imbalance likely leads to slower overall drug metabolism, increasing the risk of side effects.

A Hypothetical Drug Has a Side Effect of Increasing Blood