The sickness whooping cough is caused by infection with the bacterium Bordetella pertussis, which produces pertussis toxin.This toxin inhibits the activity of a protein that regulates adenylyl cyclase.One symptom of this inhibition is the development of a severe cough that can be so strong that it breaks ribs.Vaccines for B.pertussis are effective, but the bacterium can develop sequence differences that allow it to escape detection by the immune system.To develop an updated vaccine that confers immunity to a new strain of B.pertussis, researchers would

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To develop an updated vaccine that confers immunity to a new strain of B.pertussis, researchers would need to compare the genomes of old and new strains to identify the sequence differences that allow the bacterium to escape detection by the immune system. This would enable them to create a vaccine that targets the new strain's specific antigens. Therefore, comparing the genomes of old and new strains is the best choice.

The Sickness Whooping Cough Is Caused by Infection with the Bacterium