Binding of a Molecule from a Pathogen to a Receptor $\rightarrow$

Binding of a molecule from a pathogen to a receptor initiates a signal transduction pathway.Which represents the correct order of events in this pathway?

A) Change in shape of NF-κB $\rightarrow$ binding of NF-κB to the promoter $\rightarrow$ activation of toll-like receptor $\rightarrow$ transcription of defense genes
B) Binding of NF-κB to the promoter $\rightarrow$ change in shape of NF-κB $\rightarrow$ activation of toll-like receptor $\rightarrow$ transcription of defense genes
C) Activation of toll-like receptor $\rightarrow$ change in shape of NF-κB $\rightarrow$ binding of NF-κB to the promoter $\rightarrow$ ranscription of defense genes
D) Activation of toll-like receptor $\rightarrow$ binding of NF-κB to the promoter $\rightarrow$ change in shape of NF-κB $\rightarrow$ transcription of defense genes
E) Binding of NF-κB to the promoter $\rightarrow$ activation of toll-like receptor $\rightarrow$ transcription of defense genes $\rightarrow$ change in shape of NF-κB