To Adequately Test a Vaccine for Its Effectiveness Against HIV

To adequately test a vaccine for its effectiveness against HIV, one would need to determine if it

A) stimulates production of antibodies against HIV, indicating a robust humoral immune response, only.
B) stimulates production of cytotoxic T cells against HIV, indicating a robust cellular immune response, only.
C) stimulates production of both antibodies against HIV and cytotoxic T cells against HIV-infected cells.
D) stimulates a robust innate immune response, producing macrophages that phagocytizes infected cells.
E) activates Toll-like receptors against pathogen-associated molecular patterns (PAMPs) specific to HIV.