A key property of opioid drugs which underlies their addiction liability is their ability to indirectly activate _________________________ neurons projecting to the nucleus accumbens.

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Opioid drugs activate dopaminergic neurons projecting to the nucleus accumbens, which is a key aspect of their addiction liability. Activation of these neurons results in the release of dopamine, a neurotransmitter associated with feelings of pleasure and reward, which can reinforce drug-taking behavior.

A Key Property of Opioid Drugs Which Underlies Their Addiction