Research using antagonist-precipitated withdrawal indicates that the ________ plays a key role in producing opiate withdrawal symptoms.
A) amygdala
B) orbitofrontal cortex
C) hypothalamus
D) locus coeruleus
E) reticular formation

Question

Quizplus · Accepted Answer

Research using antagonist-precipitated withdrawal, such as with naloxone, suggests that the locus coeruleus plays a key role in producing opiate withdrawal symptoms. The locus coeruleus is a small nucleus in the brainstem that contains noradrenergic neurons and is involved in the stress response, arousal, and vigilance. When opioids bind to receptors on these neurons, they inhibit their firing and reduce the release of norepinephrine. When the opioids are suddenly removed, such as with naloxone, the neurons fire more rapidly and release more norepinephrine, leading to the symptoms of withdrawal.

Research Using Antagonist-Precipitated Withdrawal Indicates That the ________ Plays a Key