Withdrawal from alcohol use leads to seizures, which may reflect
A) damage to cholinergic cells in the hippocampus.
B) an upregulation of GABA transmission in brain.
C) facilitation of activity at NMDA receptors.
D) release of GABA within the cerebellum.
E) more long-term potentiation within the cortex.

Question

Quizplus · Accepted Answer

Withdrawal from alcohol use leads to hyperexcitability in the brain due to a decrease in GABA transmission and an increase in NMDA receptor activity. This can lead to seizures, indicating the facilitation of activity at NMDA receptors.

Withdrawal from Alcohol Use Leads to Seizures, Which May Reflect