The margin of safety is ________ than the therapeutic index.

Question

Quizplus · Accepted Answer

The margin of safety is more conservative in the direction of safety than the therapeutic index. The margin of safety gives a measure of the safety of a drug by comparing the minimum toxic dose to the minimum effective dose, while the therapeutic index compares the minimum toxic dose to the minimum effective dose. The margin of safety is a more conservative measure of safety because it only considers the minimum effective dose, while the therapeutic index also considers the minimum toxic dose. Therefore, the margin of safety is a better measure of safety when the goal is to avoid toxicity.

The Margin of Safety Is ________ Than the Therapeutic Index