A patient with Alport's syndrome is usually a male who presents with poor kidney function and blood in the urine. The mutation causing this syndrome involves the gene for the $\alpha$-3 chain of type IV collagen. The reason why the patient is usually a male is that

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Alport's syndrome is an X-linked disorder, meaning that the gene mutation occurs on the X chromosome. Females have two X chromosomes, and males have one X and one Y chromosome, so males are more likely to be affected by the syndrome.

A Patient with Alport's Syndrome Is Usually a Male Who α\alphaα

A Patient with Alport's Syndrome Is Usually a Male Who $\alpha$