Which Will Be True for Any Actual or Potential Nucleophilic $\Delta$

Which will be true for any actual or potential nucleophilic substitution reaction?

A) " $\Delta$ H ^$\circ$ is positive."
B) " $\Delta$ H ^$\circ$ is negative."
C) " $\Delta$ G^‡ is positive."
D) " $\Delta$ G ^$\circ$ is positive."
E) " $\Delta$ G ^$\circ$ is negative."