High fidelity DNA replication and repair

Question

Quizplus · Accepted Answer

High fidelity DNA replication and repair are due to the combined proofreading functions found on DNA polymerase I and III. These proofreading functions allow for the correction of errors during DNA synthesis, ensuring that the newly replicated DNA strand is an exact copy of the original. RecBCD protein complex is involved in DNA repair, but not necessarily in high fidelity replication. The lexA protein and the SOS response are involved in DNA damage response, but not directly in high fidelity replication. The formation of chi form intermediates is a mechanism of homologous recombination and not of high fidelity replication. Nucleic acid structure alone cannot ensure high fidelity replication and repair.

High Fidelity DNA Replication and Repair