A major control point of the Krebs cycle is exerted at the level of

Question

Quizplus · Accepted Answer

Citrate synthase is the enzyme that catalyzes the first step in the Krebs cycle, which is the condensation of acetyl-CoA and oxaloacetate to form citrate. This reaction is energetically favorable and irreversible, making it a major control point of the cycle. The regulation of citrate synthase activity can occur through allosteric inhibition by ATP, NADH, and succinyl-CoA, as well as through feedback inhibition by citrate.

A Major Control Point of the Krebs Cycle Is Exerted