The steady-state activity of pyruvate dehydrogenase (PDH) is reduced by increases in all of the following EXCEPT

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Quizplus · Accepted Answer

Increases in cyclic AMP, a signaling molecule that activates protein kinase A (PKA), actually stimulates PDH activity by phosphorylating the enzyme complex. Increases in acetyl CoA, NADH, and ATP all contribute to negative feedback regulation of PDH activity, while ingestion of ethanol leads to the formation of acetate and NADH, both of which can inhibit PDH activity.

The Steady-State Activity of Pyruvate Dehydrogenase (PDH) Is Reduced by Increases