The nurse is administering medications to a patient who is receiving cyclosporine [Sandimmune]. Which medication,when administered concurrently with cyclosporine,would warrant a reduction in the dosage of cyclosporine?

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Concurrent use of ketoconazole would warrant a reduction in the dosage of cyclosporine. Ketoconazole often is given concurrently with cyclosporine so that the patient's dosage of cyclosporine,which is costly,can be reduced. Phenytoin would cause a decrease in cyclosporine levels. Prednisone often is given concurrently with cyclosporine to suppress the immune response. Trimethoprim/sulfamethoxazole reduces levels of cyclosporine in the body.

The Nurse Is Administering Medications to a Patient Who Is