What Does Substance Withdrawal Refer To

What does substance withdrawal refer to?

A) A set of maladaptive physiological and behavioural symptoms that result when a person who has used a substance heavily for a prolonged period stops or greatly reduces their use of the substance
B) A set of behavioural and psychological changes that occur as a direct result of the physiological effects of a substance on the central nervous system
C) A condition that occurs when a person's recurrent use of a substance results in significant harmful consequences
D) A condition that occurs when a person experiences less and less of an effect from the same dose of a substance and needs greater and greater amounts to achieve intoxication