Which of the following substances has the lowest risk of tolerance?

Question

Quizplus · Accepted Answer

PCP (Phencyclidine) has a lower risk of tolerance development compared to alcohol, heroin, and nicotine. Tolerance refers to a reduced response to a drug after repeated use, necessitating higher doses to achieve the same effect. PCP's unique mechanism of action, including its effects on the NMDA receptor, contributes to its lower propensity for tolerance development compared to substances like alcohol, heroin, and nicotine, which more directly and consistently activate reward pathways and have mechanisms that more readily lead to tolerance.

Which of the Following Substances Has the Lowest Risk of Tolerance