In Sickle-Cell Disease,
A) a Clotting Factor in the Blood $\beta$

In sickle-cell disease,

A) a clotting factor in the blood is nonfunctional.
B) the sixth amino acid is changed from a valine to a glutamic acid.
C) the sixth amino acid is changed to a stop codon.
D) hemoglobin builds up in the red blood cells.
E) the structure of $\beta$ -globin is altered, and the hemoglobin protein forms aggregates in the red blood cells.