Which of the following mutations would probably be the most deleterious?

Question

Quizplus · Accepted Answer

A frame-shift mutation in the second codon would have the most deleterious impact because it would change the entire amino acid sequence downstream of the mutation, leading to a non-functional or drastically altered protein. A missense mutation in the second codon or a silent mutation in the second codon would have less of an effect because there may still be a functional protein produced. A nonsense mutation in the last codon may lead to a truncated protein but it would still retain some functionality, whereas a missense mutation in the last codon may have no effect at all if it codes for a non-essential amino acid.

Which of the Following Mutations Would Probably Be the Most