A nonsense mutation occurs when a point mutation changes a codon that codes for an amino acid into a stop codon, resulting in premature termination of translation and a truncated non-functional protein. This type of mutation can have significant effects on protein function and activity.

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A Nonsense Mutation

Question 138

Multiple Choice

A nonsense mutation

A) is a result of a change in a codon for an amino acid in a protein to a stop codon.
B) results in a shorter mRNA transcript of the gene.
C) results in a protein that is truncated from the N-terminal end.
D) would likely not affect the activity of a protein.
E) would not affect the primary structure of a protein.

Correct Answer: