Undesired polysubstitution of an aromatic nucleus is most likely to be encountered in the case of:
A)Friedel-Crafts alkylation
B)Friedel-Crafts acylation
C)Nitration
D)Sulfonation
E)Chlorination

Question

Quizplus · Accepted Answer

Friedel-Crafts alkylation reactions are more prone to undesired polysubstitution of an aromatic ring as the alkylating agent can undergo further substitution reactions leading to multiple alkyl groups on the ring. On the other hand, Friedel-Crafts acylation, nitration, sulfonation, and chlorination reactions typically lead to mono-substituted products as the reactions are less likely to proceed beyond one substitution.

Undesired Polysubstitution of an Aromatic Nucleus Is Most Likely to Be