Which compound would be most reactive toward nucleophilic acyl addition-elimination? A)CH₃CHO B)CH₃COCl C)(CH₃CO)₂O D)CH₃CONH₂ E)CH₃CO₂CH₃

Question

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Compound B contains a highly reactive acyl chloride group (COCl) which is more easily attacked by nucleophiles compared to the other compounds. In addition, the resulting carboxylic acid product will be better able to leave via elimination compared to other compounds.

Which Compound Would Be Most Reactive Toward Nucleophilic Acyl Addition-Elimination