Which compound would be most reactive toward nucleophilic acyl addition-elimination?
A)Acetaldehyde
B)Acetyl chloride
C)Acetic anhydride
D)Acetamide
E)Methyl acetate

Question

Quizplus · Accepted Answer

Acetyl chloride is the most reactive toward nucleophilic acyl addition-elimination because it is a highly reactive acid chloride. It readily reacts with nucleophiles to form acyl derivatives through an addition-elimination mechanism. The other compounds listed are less reactive or have other functional groups that would interfere with the reaction.

Which Compound Would Be Most Reactive Toward Nucleophilic Acyl Addition-Elimination