Lithium salts have been used for years for the treatment of manic depression. Although its mechanism of action at the molecular level is far from clear, it has been shown that Li⁺: A) alters the conformation of a number of plasma protein receptors. B) increases the GTPase activity of G-proteins. C) inhibits a number of enzymes in phosphoinositide metabolism. D) inhibits Ca⁺⁺ release from cytoplasmic organelles. E) activates protein kinase A much like cAMP does.

Question

Quizplus · Accepted Answer

Lithium salts have been shown to inhibit enzymes involved in phosphoinositide metabolism, which in turn affects signaling pathways involved in neurotransmission and mood regulation. This is believed to be the main mechanism of action for its effectiveness in treating bipolar disorder.

Lithium Salts Have Been Used for Years for the Treatment