____ of Tyr⁵²⁷ in the SH2 domain of protein tyrosine kinase pp60^c⁻^src ____ tyrosine kinase activity by moving an "activation loop" ____ the active site. A) Phosphorylation; activates; away from B) Phosphorylation; inhibits; into C) Dephosphorylation; inhibits; away from D) Dephosphorylation; activates; into E) none are true

Question

Quizplus · Accepted Answer

Phosphorylation of Tyr527 in the SH2 domain of pp60^c-src inhibits tyrosine kinase activity by stabilizing the inactive conformation, moving the activation loop into the active site.

____ of Tyr527 in the SH2 Domain of Protein Tyrosine

____ of Tyr⁵²⁷ in the SH2 Domain of Protein Tyrosine