All are characteristic of EF-hand proteins EXCEPT: A) EF-hand domains usually are arranged so that two EF-hand domains directly contact each other. B) EF-hand proteins dramatically change conformation upon binding Ca⁺⁺ ions. C) Conformational changes promote binding of the EF-hand protein with its target protein(s). D) CaM (a EF-hand protein) binds target protein with basic amphiphilic alpha helix (Baa helix) motifs. E) All are characteristic.

Question

Quizplus · Accepted Answer

All the statements provided are characteristic of EF-hand proteins, making option E correct. EF-hand domains often contact each other, these proteins undergo significant conformational changes upon calcium ion binding, these changes facilitate interaction with target proteins, and CaM, a well-known EF-hand protein, indeed binds to target proteins with basic amphiphilic alpha helix motifs.

All Are Characteristic of EF-Hand Proteins EXCEPT