In general, proteins whose folding is chaperone-dependent start the folding process first with ____ and then are passed as ____ folded intermediates to ____.
A) Hsp40; un-; Hsp70
B) Hsp90; un-; chaperonin
C) Hsp70; partially; chaperonin
D) Hsp40; partially; Hsp70
E) Hsp60; partially; Hsp40

Question

Quizplus · Accepted Answer

Chaperone-dependent folding usually involves Hsp70 chaperones that bind to the unfolded protein and gradually stabilize it as partial folds are formed. Then, a chaperonin like Hsp60 uses ATP to encapsulate the partially folded protein and folds it into the native conformation. The Hsp40 co-chaperone may assist Hsp70 in substrate binding and hand off to Hsp60. Therefore, the correct order is Hsp70, partially folded intermediates, and then chaperonin like Hsp60.

In General, Proteins Whose Folding Is Chaperone-Dependent Start the Folding