Which of the following proteins would be commonly ubiquitinated and thus degraded by the proteasome?
A) proteins with Met as the N-terminal amino acid
B) proteins with short sequences rich in Pro, Glu, Ser and Thr
C) proteins with short sequences rich in Trp, Thr, and Phe
D) proteins having a C-terminal Cys for the formation of a thioester bond with ubiquitin
E) none of the above

Question

Quizplus · Accepted Answer

Proteins with short sequences rich in Pro, Glu, Ser and Thr are commonly targeted for degradation by ubiquitination and subsequent proteasomal degradation. This is because these amino acids are often found in unstructured or flexible regions of proteins, which are more susceptible to misfolding and aggregation. Ubiquitination of these regions marks the protein for degradation by the proteasome.

Which of the Following Proteins Would Be Commonly Ubiquitinated and Thus