Which of the following correctly describes the order of events in the class I aminoacyl-tRNA synthetase reaction?
I. displacement of AMP
II. transesterification
III. nucleophilic attack by 2′-hydroxyl of the tRNA on the acyl adenylate
IV. formation of acyl adenylate by reaction of amino acid with ATP
V. displacement and subsequent hydrolysis of pyrophosphate
A) III, I, IV, V, II
B) III, V, IV, I, II
C) IV, II, I, III, V
D) IV, V, III, I, II
E) IV, I, III, II, V
Correct Answer:
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