Which of the following statements explains why allopurinol is able to prevent gout?
A) it binds to uric acid thus preventing the formation of uric acid crystals
B) it acts as a diuretic to increase the elimination of uric acid
C) it inhibits the production of uric acid and allows for the more highly soluble xanthine and hypoxanthine to be excreted from the body
D) it stimulates the purine salvage pathway, thus eliminating the need for production of uric acid
E) none of the above
Correct Answer:
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Q1: The fate of IMP is regulated by
Q3: Many _ and _ are inhibitors of
Q4: Glutamine phosphoribosyl pyrophosphate amidotransferase catalyzes step 2
Q5: All are substrates of carbamoyl phosphate synthetase
Q6: In purine biosynthesis when glycine adds to
Q7: All are characteristics of xanthine oxidase EXCEPT:
A)
Q8: What is the function of phosphoribosyltransferases?
A) they
Q9: All are characteristics of Lesch-Nyhan Syndrome EXCEPT:
A)
Q10: The reaction, base + PRPP → nucleoside-5-phosphate
Q11: What is the common product of purine
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