Thymidylate synthase synthesizes dTMP from ____ by ____ utilizing the coenzyme ____.
A) dCTP; carboxylation; biotin
B) dUMP; methylation; THF
C) dCMP; methylation; THF
D) dGMP; phosphorylation; ATP
E) dUMP; phosphorylation; ATP

Question

Quizplus · Accepted Answer

Thymidylate synthase synthesizes dTMP from dUMP by methylating it with a methyl group derived from the coenzyme tetrahydrofolate (THF). THF is a carrier of one-carbon units and is involved in the synthesis of nucleotides and amino acids. Choice A is incorrect because dCTP is not a substrate for thymidylate synthase and biotin is not a coenzyme involved in the reaction. Choice C is incorrect because dCMP is not a substrate for thymidylate synthase. Choice D is incorrect because thymidylate synthase does not phosphorylate nucleotides and ATP is not a coenzyme involved in the reaction. Choice E is incorrect because thymidylate synthase does not phosphorylate nucleotides and ATP is not a coenzyme involved in the reaction.

Thymidylate Synthase Synthesizes DTMP from ____ by ____ Utilizing the Coenzyme

Thymidylate Synthase Synthesizes DTMP from by Utilizing the Coenzyme