Which of the following is the mechanism of action of 5-fluorouracil?
A) competitive inhibitor of dihydrofolate reductase
B) suicide substrate for thymidylate synthase
C) competitive inhibitor of ribonucleotide reductase
D) non-competitive inhibitor of thioredoxin reductase
E) none of the above

Question

Quizplus · Accepted Answer

5-fluorouracil is a suicide substrate for thymidylate synthase, meaning that it incorporates into DNA as a false nucleotide, leading to DNA damage and ultimately cell death.

Which of the Following Is the Mechanism of Action of 5-Fluorouracil