The high free energy change for the conversion of PEP to pyruvate is due largely to the ____ conversion of the relatively unstable ____ tautomer of pyruvate to the more stable ____ form following the phosphoryl group transfer step.

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The high free energy change for the conversion of phosphoenolpyruvate (PEP) to pyruvate is due largely to the favorable conversion of the relatively unstable enol tautomer of pyruvate to the more stable keto form following the phosphoryl group transfer step. This tautomerization releases additional energy, making the overall reaction highly exergonic.

The High Free Energy Change for the Conversion of PEP