The cause of cell sickling in sickle cell anemia is:
A) interaction of oxy-Hb S with the cell membrane.
B) precipitation of deoxy-Hb S into long, chain-like fibers.
C) formation of oxy-Hb S complexes and subsequent cell disruption.
D) precipitation of Hb S - Hb A hybrid molecules.
E) none of the above.

Question

Quizplus · Accepted Answer

In sickle cell anemia, the mutation in the beta-globin gene leads to the production of abnormal hemoglobin (Hb S), which tends to aggregate into long, rigid, insoluble fibers when it gives up its oxygen molecule. These fibers cause the erythrocytes to assume a sickle shape, which can result in obstruction of small blood vessels and lead to tissue damage, pain, and other complications.

The Cause of Cell Sickling in Sickle Cell Anemia Is