In the glutamate:aspartate aminotransferase catalyzed reaction mechanism, glutamate would react with ____ to form α-ketoglutarate.
A) E-pyridoxal phosphate complex
B) E-pyridoxamine phosphate complex
C) aspartate
D) oxaloacetate
E) none of the above

Question

Quizplus · Accepted Answer

Glutamate reacts with the E-pyridoxal phosphate (PLP) complex to form an intermediate which then reacts with the second substrate, either aspartate or α-ketoglutarate, to form the respective product. In the case of forming α-ketoglutarate, the intermediate is decarboxylated, and the resulting product is α-ketoglutarate.

In the Glutamate:aspartate Aminotransferase Catalyzed Reaction Mechanism, Glutamate Would React