All of the following statements about noncompetitive inhibition are true EXCEPT: A) They interact with the enzyme as well as the enzyme-substrate complex. B) Increasing the concentration of [S] can overcome the inhibition. C) The V_max value does not remain the same as for a reaction that is not inhibited. D) The inhibitor can cause a conformational change in the enzyme. E) The inhibitor binds to a different site than does the substrate.

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Quizplus · Accepted Answer

Noncompetitive inhibition is a type of inhibition where the inhibitor binds to a site on the enzyme that is separate from the active site. This results in a conformational change that alters the shape of the active site, making it less effective at catalyzing the reaction. Options A, C, D, and E are all true statements about noncompetitive inhibition, but increasing the concentration of substrate cannot overcome the inhibition because the inhibitor does not bind to the active site.

All of the Following Statements About Noncompetitive Inhibition Are True