Nucleosomes very close to the transcription start site in eukaryotes tend to have a high proportion of the histone variants H3.3 and H2A.Z.

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This statement is true. Studies have shown that nucleosomes located near the transcription start site in eukaryotes tend to contain a higher proportion of the histone variants H3.3 and H2A.Z compared to other nucleosomes in the genome. These histone variants may play a role in regulating gene expression by altering the chromatin structure and accessibility of DNA to transcription factors.

Nucleosomes Very Close to the Transcription Start Site in Eukaryotes