Which of the following BEST explains the "wobble" hypothesis proposed by Francis Crick?
A) The genetic code is degenerate in that most amino acids have more than one codon.
B) The genetic code is ambiguous in that each codon can specify more than one amino acid.
C) The anticodon can pair with any part of the corresponding codon.
D) The 5' base of the anticodon can make non Watson-Crick hydrogen bonds with several different bases at the 3' position of the codon.
E) Inosine can pair up with A, U, or C.

Question

Quizplus · Accepted Answer

The "wobble" hypothesis proposed by Francis Crick explains that the 5' base of the anticodon can make non Watson-Crick hydrogen bonds with several different bases at the 3' position of the codon, allowing flexibility in the pairing of the codon and anticodon. This hypothesis explains why some tRNA molecules can recognize more than one codon, and why there is degeneracy in the genetic code. Therefore, choice D is the best answer.

Which of the Following BEST Explains the "Wobble" Hypothesis Proposed