One trial that clearly illustrated problems with gene therapy was among children with severe combined immunodeficiency. What was the serious secondary effect believed to be a result of this form of therapy?

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The serious secondary effect of the gene therapy trial among children with severe combined immunodeficiency was the development of leukemia in some of the treated patients. The therapy involved the use of a retrovirus to introduce a functional copy of the gene into the patients' immune cells, but in some cases, this caused the activation of oncogenes and the development of leukemia.

One Trial That Clearly Illustrated Problems with Gene Therapy Was