Which of the Following Practices Is NOT Associated with Rational

Which of the following practices is NOT associated with rational prescribing of antidepressants?

A) The use of a combination of antidepressant agents is the best way of treating depression.
B) When changing antidepressant agents, the patient should have a 'washout' period.
C) If one antidepressant does not work at therapeutic doses, the patient should be changed to another antidepressant.
D) Significant antidepressant benefit is not apparent immediately upon starting treatment. The prescriber should wait three to four weeks before assessing the benefit.