In bipolar diseases, there are ______ in prefrontal activation during the depressive phase and ______ in activation in the anterior limbic network during the manic phase.

Question

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During the depressive phase of bipolar disorder, there is a decrease in prefrontal activation. However, during the manic phase, there is an increase in activation in the anterior limbic network, which is involved in emotional processing and regulation.

In Bipolar Diseases, There Are ______ in Prefrontal Activation During