To minimise the increased incidence of acute gouty attacks at the start of allopurinol treatment,________ should be given concurrently for the first two months of treatment.
A) colchicine or an NSAID
B) probenecid
C) an intra-articular injection of methylprednisolone
D) a urinary alkaliser such as sodium bicarbonate

Question

Quizplus · Accepted Answer

Concurrent administration of colchicine or an NSAID for the first two months of allopurinol treatment can reduce the likelihood of acute gouty attacks. Both these drugs have anti-inflammatory effects that can help manage and prevent gout flares. Probenecid and urinary alkalizers are not recommended for use in acute gout flares. Intra-articular injection of methylprednisolone may be considered in patients with severe acute gouty arthritis, but it is not a standard part of gout management during allopurinol initiation.

To Minimise the Increased Incidence of Acute Gouty Attacks at the Start