The DNA polymerases in a relatively large family of polymerases in which each member is specialized for incorporating nucleotides opposite particular types of DNA lesions in the template strand engage in a type of DNA synthesis called __________.They have an unusually spacious active site that ____________.
A)translesion synthesis,unwinds DNA double helices
B)translesion synthesis; is able to physically accommodate altered nucleotides that would not fit in the active site of a replicative polymerase
C)transdimensional synthesis; incorporates the nucleotide that would have paired with the undamaged version of the template base
D)transdimensional synthesis; unwinds DNA synthesis
E)transliteral synthesis; is able to physically accommodate altered nucleotides that would not fit in the active site of a replicative polymerase

Question

Quizplus · Accepted Answer

The given description matches the process of translesion synthesis, which is performed by specialized DNA polymerases that are able to incorporate nucleotides opposite certain kinds of DNA lesions. These polymerases have a more spacious active site that can accommodate altered nucleotides that do not fit in the active site of normal DNA polymerases used in replication. Hence, option B is the correct choice.

The DNA Polymerases in a Relatively Large Family of Polymerases