How are integral membrane proteins thought to enter the lipid bilayer?
A)They insert into the membrane from the RER lumen after their synthesis is complete.
B)The aqueous translocon channel seems to have a gate that continuously opens and closes,giving each nascent polypeptide segment a chance to partition itself into the lipid bilayer's hydrophobic core.
C)They insert into the membrane from the cytosol after their synthesis is complete.
D)It is thought that they burrow into the lipid bilayer.
E)It is thought that they are enzymatically implanted in the lipid bilayer.

Question

Quizplus · Accepted Answer

Integral membrane proteins are thought to enter the lipid bilayer through the aqueous translocon channel, which opens and closes to allow the nascent polypeptide segment to partition itself into the hydrophobic core of the membrane. This process is aided by the presence of specific amino acid sequences that act as signals for membrane insertion. Once in the membrane, the protein may undergo conformational changes to achieve its functional structure.

How Are Integral Membrane Proteins Thought to Enter the Lipid