How and where is the asymmetry of the phospholipid bilayers initially established?
A)It is initially established in the Golgi complex during lipid and protein modification.
B)It is initially established in the ER during lipid and protein synthesis.
C)It is initially established in the secretory vesicles during lipid and protein modification
D)It is initially established in the mitochondria by random insertion into the membranes.
E)All of these are correct.

Question

Quizplus · Accepted Answer

The asymmetry of the phospholipid bilayers is initially established in the endoplasmic reticulum (ER) during lipid and protein synthesis. Enzymes in the ER membrane selectively add different lipid species to each side of the bilayer, resulting in distinct lipid compositions and bilayer asymmetry. This initial asymmetry can be further modified in other organelles, such as the Golgi complex, but it is first established in the ER.

How and Where Is the Asymmetry of the Phospholipid Bilayers