How do protein coats select the cargo molecules to be carried by the vesicles they help to form?
A)They electromagnetically attract the correct cargo proteins.
B)The protein coats have a specific affinity for the cytosolic tails of integral membrane proteins that reside in the donor membrane.
C)The coats have a specific affinity for the luminal tails of integral membrane proteins that reside in the donor membrane.
D)The coat proteins directly attach to the cargo proteins in the lumen of the forming vesicles.
E)The coat proteins attach to the extracellular matrix.

Question

Quizplus · Accepted Answer

Protein coats, such as clathrin or COPII, have a specific affinity for the cytosolic tails of integral membrane proteins that reside in the donor membrane. This allows them to select and capture the specific cargo molecules to be carried by the vesicles they form. The coat proteins do not directly attach to the cargo proteins in the lumen of the forming vesicles or to the extracellular matrix.

How Do Protein Coats Select the Cargo Molecules to Be