For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. )
-A 60-year-old man is evaluated for shortness of breath,lightheadedness,diarrhea,abdominal pain,and tingling in his fingers and toes.A blood smear from the patient is shown in the figure.Antibodies to intrinsic factor are detected in his serum.

A)Type I hypersensitivity
B)Type II hypersensitivity
C)Type III hypersensitivity
D)Type IV hypersensitivity

Question

For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. )
-A 60-year-old man is evaluated for shortness of breath,lightheadedness,diarrhea,abdominal pain,and tingling in his fingers and toes.A blood smear from the patient is shown in the figure.Antibodies to intrinsic factor are detected in his serum.
 
A)Type I hypersensitivity 
B)Type II hypersensitivity 
C)Type III hypersensitivity 
D)Type IV hypersensitivity

Quizplus · Accepted Answer

This patient has pernicious anemia,a type II hypersensitivity disease in which autoantibodies against intrinsic factor of gastric parietal cells lead to neutralization of intrinsic factor,which is required for intestinal absorption of vitamin B12.Deficiency in vitamin B12 leads to abnormal erythropoiesis with macrocytic anemia and hypersegmented neutrophils (as shown in the figure).

For Each of the Clinical Scenarios in Questions ,Choose the Hypersensitivity