For each of the clinical scenarios in questions ,choose the hypersensitivity type (A-D)that best matches the associated immunologic disease.(Answers may be used more than once. )
-A 29-year-old woman gives birth to an infant who is lethargic,jaundiced,and severely anemic and has an enlarged liver and spleen.The mother is RhD negative and the father is homozygous RhD positive.This is their second child.
A)Type I hypersensitivity
B)Type II hypersensitivity
C)Type III hypersensitivity
D)Type IV hypersensitivity

Question

Quizplus · Accepted Answer

This condition,called erythroblastosis fetalis,is a severe form of hemolytic disease of the newborn that occurs when an Rh-negative mother gives birth to an infant who is Rh positive (since the father is homozygous Rh positive).In this disease,the mother produces IgG antibodies against Rh-positive cells to which she has been previously exposed (i.e. ,during the delivery of her first Rh-positive child).Because the mother's immune system recognizes Rh antigen as "foreign," she produced large amounts of anti-Rh antibody when she encountered the antigen during the second pregnancy.This antibody crossed the placenta and mediated cellular injury in the second infant.Therefore,this is an example of type II hypersensitivity.Note that the most commonly involved antigen in erythroblastosis fetalis is RhD.

For Each of the Clinical Scenarios in Questions ,Choose the Hypersensitivity