The tumor necrosis factor (TNF)family of proteins includes several soluble and membrane proteins that share structural homologies.All members of this family bind to members of the TNF-receptor family of molecules expressed on cell surfaces.TNF-R family members are structurally homologous to one another and utilize similar signal transduction pathways.
For each description of a TNF or a TNF-R family member in questions ,select the term listed in options A-E that best matches it.
-Expressed on macrophages and B lymphocytes,this receptor plays an important role in the helper T cell-mediated effector functions.

Question

Quizplus · Accepted Answer

CD40 is a member of the tumor necrosis factor receptor family expressed by B cells,macrophages.CD40 binds CD40 ligand on activated helper T cells,and ligand binding initiates signaling pathways that activate macrophages and B lymphocytes.CD40-mediated macrophage activation leads to enhanced phagocytic and microbicidal functions,and CD40-mediated B cell activation is essential for T follicular helper cell-dependent Ig isotype switching and affinity maturation.

The Tumor Necrosis Factor (TNF)family of Proteins Includes Several Soluble