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In the First Few Days Following Organ Transplantation, Patients Are

Question 1

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In the first few days following organ transplantation, patients are often treated with several doses of an antibody mixture known as anti-thymocyte globulin. The anti-thymocyte globulin is generated by immunizing rabbits or horses with human T cells, to generate antibodies against the human T cell surface molecules. Following the anti-thymocyte globulin treatment, patients are generally put on a sustained regimen of cyclosporin A or other small-molecule immunosuppressive drugs. The immediate post-operative treatment with anti-thymocyte globulin is likely used to:


A) Activate the patient's T cells in vivo to prevent infections
B) Enhance the binding of the T-cell receptor to peptide:MHC on the graft
C) Temporarily deplete the patient's T cells
D) Allow the clinicians to monitor the patient's T cell numbers by flow cytometry
E) Stimulate the development of FoxP3+ Treg cells

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